Nature Chemistry, Published online: 28 May 2025; doi:10.1038/s41557-025-01830-y
Models of abiotic RNA replication suffer from inherent product inhibition arising from the high stability of RNA duplexes. Now, it has been shown that RNA trinucleotide substrates undergoing simple physicochemical cycles can overcome this problem, enabling open-ended replication of defined and random RNA sequences by a polymerase ribozyme.
Nature Chemistry, Published online: 28 May 2025; doi:10.1038/s41557-025-01830-yModels of abiotic RNA replication suffer from inherent product inhibition arising from the high stability of RNA duplexes. Now, it has been shown that RNA trinucleotide substrates undergoing simple physicochemical cycles can overcome this problem, enabling open-ended replication of defined and random RNA sequences by a polymerase ribozyme. Read More
