Malaria-on-a-Chip Phenotypic Disease Model
In article number 2505206, James J. Hickman and co-workers describe the first digital twin derived from an organ-on-a-chip system, applied here to model Plasmodium falciparum infection and treatment. By replicating host-parasite interactions across multiple organs, the model enables quantitative prediction of clinical outcomes for antimalarial drugs. This advancement represents a major step toward more effective, human-relevant preclinical testing and offers a potential alternative to traditional animal models in infectious disease research.
Advanced Science, Volume 12, Issue 38, October 13, 2025. Read More
