Nature Reviews Chemistry, Published online: 15 December 2025; doi:10.1038/s41570-025-00779-3
This Review explores how ionizing radiation triggers drug release via water radiolysis, detailing reactive species, drug activation mechanisms and strategies for designing radiation-sensitive prodrugs and nanocarriers to enhance chemoradiation therapy with reduced systemic toxicity.
Nature Reviews Chemistry, Published online: 15 December 2025; doi:10.1038/s41570-025-00779-3This Review explores how ionizing radiation triggers drug release via water radiolysis, detailing reactive species, drug activation mechanisms and strategies for designing radiation-sensitive prodrugs and nanocarriers to enhance chemoradiation therapy with reduced systemic toxicity. Read More
