Nature Chemistry, Published online: 23 May 2025; doi:10.1038/s41557-025-01841-9
Tauopathies are neurodegenerative diseases characterized by the pathological aggregation of tau, which forms distinct polymorphic structures in a disease-specific manner. A recent study presents macrocyclic tau-mimicking peptides that structurally and functionally resemble these disease-associated folds, providing new tools for studying tau aggregation and potential therapeutic strategies.
Nature Chemistry, Published online: 23 May 2025; doi:10.1038/s41557-025-01841-9Tauopathies are neurodegenerative diseases characterized by the pathological aggregation of tau, which forms distinct polymorphic structures in a disease-specific manner. A recent study presents macrocyclic tau-mimicking peptides that structurally and functionally resemble these disease-associated folds, providing new tools for studying tau aggregation and potential therapeutic strategies. Read More
