Mask-prior-guided denoising diffusion improves inverse protein folding

Nature Machine Intelligence, Published online: 16 June 2025; doi:10.1038/s42256-025-01042-6

Bai and colleagues present MapDiff, a discrete diffusion-based framework for generating amino acid sequences conditioned on a target protein structure, with strong performance in predicting uncertain regions and achieving high in silico foldability.

​Nature Machine Intelligence, Published online: 16 June 2025; doi:10.1038/s42256-025-01042-6Bai and colleagues present MapDiff, a discrete diffusion-based framework for generating amino acid sequences conditioned on a target protein structure, with strong performance in predicting uncertain regions and achieving high in silico foldability. Read More

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