Machine learning prediction of enzyme optimum pH

Nature Machine Intelligence, Published online: 29 April 2025; doi:10.1038/s42256-025-01026-6

Accurately predicting the optimal pH level for enzyme activity is challenging due to the complex relationship between enzyme structure and function. Gado and colleagues show that a language model can effectively learn the structural and biophysical features to predict the optimal pH for enzyme activity.

​Nature Machine Intelligence, Published online: 29 April 2025; doi:10.1038/s42256-025-01026-6Accurately predicting the optimal pH level for enzyme activity is challenging due to the complex relationship between enzyme structure and function. Gado and colleagues show that a language model can effectively learn the structural and biophysical features to predict the optimal pH for enzyme activity. Read More

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