Nature Chemistry, Published online: 21 May 2025; doi:10.1038/s41557-025-01840-w
G-protein-coupled receptors (GPCRs) are linked to a plethora of human diseases, but the efficacy of drugs that target GPCRs often varies between patients. Now, a link has been established between the gut microbiome and GPCR drug metabolism, in which the identities of the microbes directly influence the metabolites formed and the host drug response.
Nature Chemistry, Published online: 21 May 2025; doi:10.1038/s41557-025-01840-wG-protein-coupled receptors (GPCRs) are linked to a plethora of human diseases, but the efficacy of drugs that target GPCRs often varies between patients. Now, a link has been established between the gut microbiome and GPCR drug metabolism, in which the identities of the microbes directly influence the metabolites formed and the host drug response. Read More
