Core diversification using 1,2-oxaborines as a versatile molecular platform

Nature Chemistry, Published online: 09 October 2025; doi:10.1038/s41557-025-01971-0

In drug discovery, the preparation of analogues with diverse core structures often requires laborious efforts. Now it has been shown that 1,2-oxaborines, which are synthesized from readily available starting materials, can serve as a versatile platform to allow rapid access to diverse central skeletons, thus simplifying the core diversification process.

​Nature Chemistry, Published online: 09 October 2025; doi:10.1038/s41557-025-01971-0In drug discovery, the preparation of analogues with diverse core structures often requires laborious efforts. Now it has been shown that 1,2-oxaborines, which are synthesized from readily available starting materials, can serve as a versatile platform to allow rapid access to diverse central skeletons, thus simplifying the core diversification process. Read More

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