Nature Chemistry, Published online: 18 November 2025; doi:10.1038/s41557-025-01998-3
Nature contains a variety of mechanostable proteins, which all bear extensive hydrogen-bond networks within their β-sheet architectures to sustain high stability under stress. Now through integrating AI-guided design alongside MD simulations and by maximizing hydrogen bonds in β strands, SuperMyo proteins with nanonewton mechanical stability and thermal resilience up to 150 °C were created.
Nature Chemistry, Published online: 18 November 2025; doi:10.1038/s41557-025-01998-3Nature contains a variety of mechanostable proteins, which all bear extensive hydrogen-bond networks within their β-sheet architectures to sustain high stability under stress. Now through integrating AI-guided design alongside MD simulations and by maximizing hydrogen bonds in β strands, SuperMyo proteins with nanonewton mechanical stability and thermal resilience up to 150 °C were created. Read More
