Chemical engineering

Reliable AI Platform for Monitoring BCI Caused Brain Injury and Providing Real‐Time Protection

BrainGuard enables real-time and interpretable assessment of brain injury caused by brain computer interface (BCI). Using feature-based Gaussian process (GP) emulators trained on limited biomechanical data, it efficiently predicts full-field strain and constructs patient-specific digital brain twins to support clinical diagnosis and long-term BCI safety. Abstract Invasive brain-computer interface (BCI) holds great promise for restoring […]

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Polarization‐Dependent 3D Holography Generated by Inverse Design Nanoprinting Metasurface

A novel polarization-dependent 3D holography is proposed by introducing polarization as an additional freedom, enabling enhanced depth selectivity and greater control over holographic reconstruction. The efforts perfectly combine the polarization and 3D holography display into ADAM gradient descent algorithm, the application of nanoprinting further makes the polarization-dependent 3D holography metasurface functional. Abstract 3D holographic imaging

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RUNX2 Activation in Fibro/Adipogenic Progenitors Promotes Muscle Fibrosis in Muscular Dystrophy

This study revealed a novel role of the chemokine-TGF-β1-RUNX2 axis in determining the fate of FAP differentiation and modulating muscle fibrosis in patients and mice with muscular dystrophies. ABSTRACT Clinical evidence indicates concurrent muscle inflammation and fibrosis in muscular dystrophies (MDs); however, the molecular mechanisms underlying inflammation-mediated fibrosis in skeletal muscle remain inadequately understood. This

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Polyoxometalate as Hydrogen–Electron Hub in Metal–Organic Complex for Electrocatalytic Nitrate Reduction to Ammonia

To tackle low electrocatalytic nitrate reduction to ammonia efficiency in neutral media, this work designs chain-like dinuclear/trinuclear polyoxometalate-based metal-organic complexes. Metal clusters provide nitrate adsorption/activation sites, while polyoxometalates (POMs) drive water dissociation to generate active hydrogen (*H) that migrates to these sites; POM-to-cluster electron transfer optimizes adsorption and lowers the rate-determining step barrier to advance

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MARPLE: A Proximity‐Triggered CRISPR‐Cas13 Platform for Ultrasensitive Antibody Detection

MARPLE is a modular CRISPR-Cas13 immunoassay that uses antibody-induced proximity to trigger a toehold-exchange reaction, releasing an RNA activator for Cas13. This one-pot, isothermal architecture enables ultrasensitive (femtomolar) and highly specific detection of diverse antibodies, including therapeutic, pathogen-specific, and cancer-associated targets, with robust performance in human serum. ABSTRACT Monitoring clinically relevant antibodies—as biomarkers of disease

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