An integrated framework to accelerate protein design through mutagenesis

Nature Machine Intelligence, Published online: 29 September 2025; doi:10.1038/s42256-025-01118-3

Designing and optimizing proteins by mutagenesis suffers from the overwhelming space of possible variants. A recent study developed µProtein, a reinforcement learning model coupled with a protein language model as a surrogate oracle, to accelerate this process towards high-functioning proteins.

​Nature Machine Intelligence, Published online: 29 September 2025; doi:10.1038/s42256-025-01118-3Designing and optimizing proteins by mutagenesis suffers from the overwhelming space of possible variants. A recent study developed µProtein, a reinforcement learning model coupled with a protein language model as a surrogate oracle, to accelerate this process towards high-functioning proteins. Read More

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