Nature Machine Intelligence, Published online: 01 October 2025; doi:10.1038/s42256-025-01120-9
Jian Ma et al. present HuDiff, a diffusion-based deep learning framework that humanizes antibodies and nanobodies (a small type of antibody) without templates. The model achieves improved humanness while preserving or enhancing binding strength, and the authors show promising results in virus neutralization experiments.
Nature Machine Intelligence, Published online: 01 October 2025; doi:10.1038/s42256-025-01120-9Jian Ma et al. present HuDiff, a diffusion-based deep learning framework that humanizes antibodies and nanobodies (a small type of antibody) without templates. The model achieves improved humanness while preserving or enhancing binding strength, and the authors show promising results in virus neutralization experiments. Read More
